Immunology in Biotechnology MCQs

Question 1

Junctional diversity of antibody molecules results from

Accepted Answer

The addition of N and P nucleotides

Answer

The addition of switch region nucleotides

Answer

The joining of V, D and J segments

Answer

Mutations in complementarity-determining regions

Question 2

Determine the correctness or otherwise of the following Assertion (A) and the Reason (R). Assertion: IgM is found in serum as a pentameric protein consisting of five IgM monomers. Reason: The pentameric form of IgM is due to cross linking of IgM monomers via peptide bond.

Accepted Answer

(A) is true but (R) is false

Answer

Both (A) and (R) are true and (R) is the correct reason for (A)

Answer

Both (A) and (R) are true but (R) is not the correct reason for (A)

Answer

(A) is false but (R) is true

Question 3

Which one of the following is NOT a part of the human non-specific defense system?

Accepted Answer

Antibody

Answer

Interferon

Answer

Mucous

Answer

Saliva

Question 4

Match the immunoglobulin class in Group I with its properties in Group II. Group I Group II P. IgG 1. Major antibody in external secretions such as bronchial mucus Q. IgA 2. Protects against parasites R. IgE 3. Antibody that appears first in serum after exposure to an antigen S. IgM 4. Antibody present in highest concentration in serum

Accepted Answer

P-4, Q-1, R-2, S-3

Answer

P-3, Q-2, R-1, S-4

Answer

P-4, Q-3, R-1, S-2

Answer

P-1, Q-4, R-3, S-2

Question 5

Reverse vaccinology indicates

Accepted Answer

From genome sequence to vaccine development

Answer

From antigenic protein to vaccine development

Answer

From antigenic polysaccharide to vaccine development

Answer

From antibody to vaccine development

Question 6

Viral replication within cells is inhibited by

Accepted Answer

IFNα

Answer

IL4

Answer

IL1

Answer

TNFα

Question 7

Antibody diversity is generated by

Accepted Answer

Inter-chromosomal recombination

Answer

Protein splicing

Answer

Somatic mutation

Answer

Allelic exclusion

Question 8

Match items in Group I with correct options from those given in Group II. Group I Group II P. Tissue plasminogen activator 1. Immunomodulator Q. Gamma interferon 2. Biodegradable plastic R. Podophyllotoxin 3. Clot dissolution S. Polyhydroxyalkanoate 4. Anti-tumor agent

Accepted Answer

P-3, Q-1, R-4, S-2

Answer

P-4, Q-3, R-1, S-2

Answer

P-1, Q-3, R-4, S-2

Answer

P-3, Q-1, R-2, S-4

Question 9

Gram-positive bacteria are generally resistant to complement-mediated lysis because

Accepted Answer

Thick peptidoglycan layer prevents insertion of membrane attack complex into the inner membrane

Answer

Gram-positive bacteria import the membrane attack complex and inactivate it

Answer

Membrane attack complex is degraded by the proteases produced by the Gram-positive bacteria

Answer

Gram-positive bacteria cannot activate the complement pathway